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Acetamoren

CAS No.: 950841-87-9
Product introduction:Acetamoren, also known by its research codes MK-677 or MK-777, is a potent, orally active, non-peptide agonist of the ghrelin receptor (growth hormone secretagogue receptor type 1a, GHS-R1a). Developed in the 1990s as a growth hormone secretagogue, its primary mechanism involves mimicking the action of endogenous ghrelin to stimulate the pulsatile release of growth hormone (GH) and subsequently increase insulin-like growth factor 1 (IGF-1) levels. This compound was initially investigated as a potential therapeutic alternative to injectable recombinant GH for treating growth hormone deficiencies and muscle-wasting disorders. More recently, it has gained significant attention in research fields exploring metabolic function, age-related sarcopenia, and recovery processes.

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CAS No.:950841-87-9

Acetamoren is a white to off-white solid powder with the molecular formula C₂₉H₃₈N₄O₆S and a molecular weight of approximately 570.71 g/mol. It is a selective agonist of the ghrelin receptor and exhibits high binding affinity, with some optimized analogs (like MK-777) reportedly demonstrating significantly greater receptor affinity than earlier versions. The compound is orally bioavailable and has a long half-life, allowing for once-daily administration in research settings. It is soluble in organic solvents such as DMSO and is recommended to be stored as a powder at 2-8°C (refrigerated) or -20°C for long-term stability, kept dry and protected from light

Core Functions:

  • Research use in metabolic studies and the physiology of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) secretion

  • Investigation into muscle preservation, prevention of age-related sarcopenia, and recovery from muscle atrophy

  • Research material for studying appetite regulation, energy homeostasis, and potential treatments for cachexia or metabolic disorders

  • Active compound in laboratory models examining bone density, soft tissue healing, and neuroplasticity

  • Reference standard for analytical method development and quality control in pharmaceutical testing

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