CAS No.: 210302-17-3
Product introduction:BAM15 (also known as N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) is a novel synthetic mitochondrial protonophore uncoupler that has garnered significant attention in metabolic and biomedical research. Unlike classical uncouplers such as FCCP or DNP, BAM15 selectively targets the inner mitochondrial membrane to dissipate the proton gradient, thereby uncoupling oxidative phosphorylation from ATP synthesis. This unique mechanism leads to increased oxygen consumption, enhanced fatty acid oxidation, and elevated energy expenditure without causing off-target effects like plasma membrane depolarization or significant cytotoxicity
CAS No.:210302-17-3
BAM15 is a white to pale-yellow or beige solid powder with the molecular formula C₁₆H₁₀F₂N₆O and a molecular weight of approximately 340.29 g/mol . Its CAS number is 210302-17-3 . The compound is highly soluble in DMSO (typically 20-63 mg/mL) but is practically insoluble in water . For research use, BAM15 is available in purities ranging from ≥98% to >99% as determined by HPLC . The compound should be stored desiccated at -20°C to maintain long-term stability, protected from light and moisture .
Core Functions:
Research tool for studying mitochondrial uncoupling, oxidative phosphorylation, and cellular energy metabolism
Investigational compound for metabolic disorders including obesity, insulin resistance, and non-alcoholic steatohepatitis (NASH)
Preclinical research on renoprotective agents for acute kidney ischemia-reperfusion injury
Anti-cancer research focusing on mitochondrial apoptosis induction and MAPK signaling inhibition
Reference standard for doping control analysis and metabolic profiling studies
Research on AMPK pathway activation and its effects on vascular smooth muscle cell function
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