Tadalafil

CAS No.:171596-29-5

Tadalafil is a white to off-white crystalline powder with the molecular formula C₂₂H₁₉N₃O₄ and a molecular weight of approximately 389.40 g/mol. Its chemical name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. The compound is practically insoluble in water but exhibits good solubility in organic solvents such as DMSO (approximately 20 mg/mL) and dimethylformamide. Tadalafil is stable under normal storage conditions when kept in a tightly sealed container, protected from light and moisture, at room temperature. It is typically available in pharmaceutical-grade purity (≥98% by HPLC) for oral formulation into film-coated tablets in various strengths (2.5 mg, 5 mg, 10 mg, and 20 mg).

Core Functions:

• Active pharmaceutical ingredient (API) in oral formulations for the treatment of erectile dysfunction (branded as Cialis®) on an as-needed or once-daily basis

• Once-daily therapy for the treatment of benign prostatic hyperplasia (BPH) and the combination of BPH and erectile dysfunction (marketed as Cialis® for BPH)

• Investigational use in the treatment of pulmonary arterial hypertension, Raynaud's phenomenon, and other conditions involving smooth muscle dysfunction

• Research use in pharmacology and urology studies of PDE5 inhibition, cGMP signaling pathways, and vascular smooth muscle physiology

• Reference standard for analytical method development and quality control in pharmaceutical testing