Blonanserin

CAS No.:132810-10-7

Blonanserin is a white to off‑white crystalline powder with the molecular formula C₂₃H₃₀FN₃ and a molecular weight of approximately 367.5 g/mol. Its chemical name is 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta(b)pyridine . The compound is soluble in organic solvents such as DMSO (at concentrations up to 10 mM) and is practically insoluble in water. For optimal stability, blonanserin powder should be stored at -20°C (or 2-8°C for short‑term use), protected from light and moisture, and is typically available in research‑grade purity (≥98% by HPLC).

Core Functions:

• Active pharmaceutical ingredient (API) in oral formulations for the treatment of schizophrenia, including the management of both positive and negative symptoms

• Active ingredient in the blonanserin transdermal patch (Lonasen® Tapes) for patients with schizophrenia, particularly those with gastrointestinal dysfunction or difficulty with oral administration 

• Investigational use in palliative care for the management of terminal delirium and refractory dyspnea in terminally ill patients with respiratory diseases

• Research use in neuropharmacology studies of dopamine D₂ and serotonin 5-HT₂A receptor antagonism, including positron emission tomography (PET) occupancy studies

• Reference standard for analytical method development and quality control in pharmaceutical testing